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1 Introduction Life expectancy in developing nations is increasing in tandem with socioeconomic progress

In this context, signalling molecule calcitonin gene-related peptide (CGRP) has received increased attention due to the effectiveness of drugs targeting CGRP signalling in treating migraine, as well as self-reported aura [7,8,9]

In summary, disruptions in copper homeostasiswhether arising from deficiency, excess, or dysfunction of molecular chaperones and transportersare fundamentally implicated in the pathogenesis of various cardiovascular diseases [30] (Figure 1)

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